ALI Initiative

Acute Lung Injury (ALI) and its more severe form, Acute Respiratory Distress Syndrome (ARDS), represent a spectrum of life-threatening inflammatory lung conditions. Characterized by a sudden onset of widespread inflammation in the lungs, ALI/ARDS disrupts the normal gas exchange process, leading to hypoxemia – a dangerously low level of oxygen in the blood. This acute respiratory failure necessitates prompt recognition and intensive care.  ALI/ARDS isn’t a primary disease but rather a complex pulmonary response to various direct or indirect insults. Common triggers include severe infections like pneumonia and sepsis, trauma, aspiration of gastric contents, and other systemic inflammatory conditions. The hallmark of ALI/ARDS is an increase in permeability of the alveolar-capillary barrier, causing protein-rich fluid to leak into the alveoli, impairing surfactant function and leading to alveolar collapse. Understanding the intricate pathophysiology of ALI/ARDS is crucial for developing effective diagnostic and therapeutic strategies aimed at improving patient outcomes.  

Research Progress

The Open Science Institute’s Acute Lung Injury research project has progressed now to the Second stage of publishing. Our goal is to raise $50,000 to go direct the research in testing, identify and combination screening of compounds on the ALI. Please support this initiative.

Systems Architecture

The Systems Architecture of acute lung injury will be published as a web-based tool, open to the public. While development is yet to commence, click below to interact with the systems architecture

Publication

A peer- reviewed publication from the ALI initiative will be relseases soon to benefit the public by revealing powerful insights into the use of Natural ingredient against the ALI- support this initiative to advance scientific discovery and deliver real solutions to the society

In silico Modeling

In this phase, the ALI Initiative will conduct in silico modeling to identify and test the natural ingredient which can effectively combat the ALI. This phase is yet to begin.

Combination Screening

Patent

The Open Science Institute® through its ALI research initiative is moving towards getting patents for a revolutionary natural compounds that may treat acute lung injury.

Licensing and Manufacturing

The ALI Initiative plans to discover, develop, license and manufacture a nutraceutical product which supports treatment of many diseases. Support our mission to bring this innovation to those who need it most. Please support this Phase by donating to the ALI Initiative