ICIS Open Science SM Card-ver2

Metabolic Health Initiative

Metabolic health refers to the optimal functioning of processes that regulate how the body uses and stores energy.

Phase I
Systems Architecture
Systems Architecture
Status: Completed
The Systems Architecture of Metabolic Health is published as a web based tool open to public.
Phase II
Publications
Publications
Status: Completed
A peer-reviewed paper from the Metabolic Health Initiative was published in 2025 in NATURE’s Systems Biology and Applications journal.
Phase III
In Silico Modeling
In Silico Modeling
Status: In Progress
In this phase, in silico modeling will develop mathematical models of Metabolic Health pathogenesis. This phase is in progress.
Phase IV
Combination Screening
Combination Screening
Status: Open
Combination Screening will be conducted to identify compounds targeting biological processes in Metabolic Health pathogenesis.
Phase V
Patents
Patents
Status: Open
In this phase, a US patent will be filed for the newly discovered combination(s).
Phase VI
Licensing and Manufacturing
Licensing and Manufacturing
Status: Open
The Metabolic Health Initiative will license and manufacture nutraceuticals to support treatment of Metabolic Health.

The Open Science Institute’s Neurodegenerative diseases Initiative has now progressed to the Third phase — In Silico Modeling. We need your support to move forward. Our goal is to raise $150,000 to research and reveal to the scientific community, highlighting the powerful potential of compounds in Metabolic health. Please support this initiative.

Background on Metabolic Health

Metabolic health refers to the optimal functioning of processes that regulate how the body uses and stores energy. It involves maintaining healthy levels of blood sugar, cholesterol, blood pressure, and waist circumference. When these parameters are within normal ranges without the use of medication, an individual is considered metabolically healthy. Key components of good metabolic health include insulin sensitivity, balanced lipid levels, stable blood pressure, and a healthy body weight. Disruptions in these processes can lead to metabolic syndrome, a cluster of conditions that increase the risk of type 2 diabetes, cardiovascular disease, stroke, and fatty liver disease. Modern lifestyles—characterized by poor diet, physical inactivity, chronic stress, and insufficient sleep—can negatively impact metabolic health. Consuming high amounts of processed foods, sugar, and unhealthy fats contributes to insulin resistance and inflammation, which are central to metabolic disorders. Improving metabolic health requires a holistic approach, including regular physical activity, a nutrient-rich diet, stress management, and adequate sleep. Monitoring health indicators and making gradual lifestyle changes can significantly reduce the risk of chronic disease. Ultimately, metabolic health is not just about weight but about how efficiently the body functions at the cellular level, supporting long-term vitality and disease prevention.

Systems Architecture

The Systems Architecture of Metabolic health is published as a Web-based tool open to public. Click below to interact with the Systems Architecture.

Publication

A peer-reviewed publication from the Metabolic health Initiative will be released soon to benefit the public by revealing powerful insights into the use of natural compounds for treating Metabolic health diseases—support this initiative to advance scientific discovery and deliver real solutions.

In Silico Modeling

In this phase, the Metabolic health Initiative will conduct in silico modeling to identify and test the efficacy of compounds on Metabolism, Dysbiosis and Anti-ulcer activity. This phase is yet to begin.

Combination Screening

In this phase, combination screening will be performed to identify potential ingredient/compounds that target the biological process implicated in Metabolic pathogenesis. This phase is yet to begin.

Patents

The Open Science Institute® through its Metabolic health initiative is moving towards getting patents for a revolutionary novel compounds that affects Metabolism, Dysbiosis and Anti-ulcer activity.

Licensing and Manufacturing

The Metabolic health Initiative plans to discover, develop, license and manufacture a Metabolic health product which supports treatment of many diseases. Support our mission to bring this innovation to those who need it most. Please support this Phase by donating to the Metabolic health Initiative