The Open Science Institute’s Osteoarthritis Initiative has been established to provide a comprehensive and integrative molecular systems understanding of human knee osteoarthritis (OA) and develop therapeutic interventions to address Osteoarthritis.The architecture is constructed through a supervised bioinformatics process beginning with nearly 20,000 scientific papers curated to a refined set of 5,243 papers from which molecular interactions are extracted. The systems architecture is accessed through an easy-to-use interface to traverse the complexity of knee OA systems biology from tissue to cell to an ensemble of molecular interactions whereby one may discover the particular paper from which an interaction is derived. The systems architecture maintains its currency by enabling the research community to provide feedback that can be reviewed, refereed and incorporated. The architecture provides a framework for developing new educational tools as well as to support research that aims to investigate disease mechanisms, and identify potential therapeutic targets for the treatment of knee OA. The exact cause of ALS is not fully understood, but both genetic and environmental factors are believed to play a role. In about 5–10% of cases, ALS is inherited (familial ALS), while the remaining 90–95% are sporadic, occurring without a clear family history. Risk factors may include age (most common between 40 and 70), gender (slightly more common in men), and exposure to certain toxins. Early symptoms of ALS may include muscle twitching, weakness in the limbs, slurred speech, or difficulty swallowing. As the disease progresses, individuals may lose the ability to walk, speak, eat, and eventually breathe. Despite the loss of motor function, cognitive abilities are often preserved. There is currently no cure for ALS, and treatment focuses on managing symptoms, improving quality of life, and prolonging survival. Medications like riluzole and edaravone can modestly slow disease progression. Supportive therapies, such as physical therapy, speech therapy, and assistive devices, play a crucial role in care. Ongoing research and awareness efforts continue in hopes of better understanding ALS, improving treatment options, and ultimately finding a cure for this devastating disease.