ALI Initiative
Acute Lung Injury (ALI) and its more severe form, Acute Respiratory Distress Syndrome (ARDS), represent a spectrum of life-threatening inflammatory lung conditions. Characterized by a sudden onset of widespread inflammation in the lungs, ALI/ARDS disrupts the normal gas exchange process, leading to hypoxemia – a dangerously low level of oxygen in the blood. This acute respiratory failure necessitates prompt recognition and intensive care. ALI/ARDS isn’t a primary disease but rather a complex pulmonary response to various direct or indirect insults. Common triggers include severe infections like pneumonia and sepsis, trauma, aspiration of gastric contents, and other systemic inflammatory conditions. The hallmark of ALI/ARDS is an increase in permeability of the alveolar-capillary barrier, causing protein-rich fluid to leak into the alveoli, impairing surfactant function and leading to alveolar collapse. Understanding the intricate pathophysiology of ALI/ARDS is crucial for developing effective diagnostic and therapeutic strategies aimed at improving patient outcomes.
Research Progress
The Open Science Institute’s Acute Lung Injury research project has progressed now to the Second stage of publishing. Our goal is to raise $50,000 to go direct the research in testing, identify and combination screening of compounds on the ALI. Please support this initiative.
Systems Architecture
The Systems Architecture of ALI is published as a web based tool open to public. Click below to interact with the Systems Architecture. Will be updated Soon
Publication
A peer- reviewed publication from the ALI initiative will be relseases soon to benefit the public by revealing powerful insights into the use of natural ingredient against the ALI support this initiative to advance scientific discovery and deliver real solutions to the society.
In silico Modeling
In this phase, in silico modeling will be performed to develop mathematical models representing the biological process involved in ALI pathogenesis. This phase is yet to begin
Combination Screening
In this phase, combination screening will be performed to identify potential ingredient/compounds that target the biological process implicated in ALI pathogenesis. This phase is yet to begin.
Patent
The Open Science Institute® through its ALI research initiative is moving towards getting patents for a revolutionary natural compounds that may support acute lung injury.
Licensing and Manufacturing
The ALI Initiative plans to discover, develop, license and manufacture a nutraceutical product which supports treatment of many diseases. Support our mission to bring this innovation to those who need it most. Please support this phase by donating to the ALI Initiative.
