Publications
The International Center for Integrative Systems (ICIS) has published papers based on research conducted in the various fields it is involved in. This page lists and links to the research papers published by ICIS.
In-Silico Analysis & In-Vivo Results Concur on Glutathione Depletion in Glyphosate Resistant GMO Soy, Advancing a Systems Biology Framework for Safety Assessment of GMOs
A recent study published in the peer-reviewed journal American Journal of Plant Sciences predicted a nearly 400% difference in glutathione oxidation as measured by the ratio of GSH and GSSG, in RRS that are glyphosate-treated glyphosate-resistant Soy versus the Organic Soy. These predictions also concur with in vivo greenhouse results. This concurrence suggests these in silico models of C1 metabolism may provide a viable and validated platform for biosafety assessment of GMOs, and aid in selecting rational criteria for informing in vitro and in vivo efforts to more accurately decide in the problem formulation phase which parameters need to be assessed so that conclusion on “substantial equivalence” or material difference of a GMO and its non-GMO counterpart can be drawn on a well-grounded basis.
Do GMOs Accumulate Formaldehyde and Disrupt Molecular Systems Equilibria?
A new study published in the peer-reviewed journal AGRICULTURAL SCIENCES applies modern computational systems biology methods to reveal genetically engineered soy (the GMO) creates significant disruption to the levels of formaldehyde, a known carcinogen, and glutathione, an important anti-oxidant necessary for cellular detoxification.
Integrative Modeling of Oxidative Stress and C1 Metabolism Reveals Upregulation of Formaldehyde and Downregulation of Glutathione
This research provides, to the authors’ knowledge, the first integrative model of oxidative stress and C1 metabolism in plants. Increased oxidative stress can cause irreversible damage to photosynthetic components and is harmful to plants. Perturbations at the genetic level may increase oxidative stress and upregulate antioxidant systems in plants.
In Silico Modeling of C1 Metabolism
This paper provides an integrative computational, in silico, model of C1 metabolism is developed from molecular pathway systems identified from a recent, comprehensive systematic bioinformatics review of C1 metabolism.
Discovery of Key Molecular Pathways of C1 Metabolism and Formaldehyde Detoxification in Maize
This paper explores a methodological process to identify key molecular pathways from systematic bioinformatics literature review. This process is used to identify molecular pathways for a ubiquitous molecular process in all plant biological systems: C1 metabolism and formaldehyde detoxification, specific to maize.
The Rosetta Stone for Siddha and Ayurveda
This paper uncovers the scientific foundation of traditional systems of Indian medicine: Siddha and Ayurveda, from core principles shared in modern control systems engineering.
Planning, Innovation and Optimization of the USPS
This paper uncovers the scientific foundation of traditional systems of Indian medicine: Siddha and Ayurveda, from core principles shared in modern control systems engineering.
Email Management & Potential Opportunities for USPS
This paper explores the idea that the Postal Service could be in the mail business be it print or electronic, given the true origin and nature of email as a system.
Connecting Buyers and Sellers at USPS
The USPS has potentially many opportunities for connecting buyers and sellers within the International Small Business Commerce market. This paper by ICIS explores the possibilities for the USPS.
International Small Business Commerce (ISBC):Potential Source of New Revenue for the United States Postal Service
This paper by ICIS studies how to potentially generate new sources of revenue for USPS, as it may be uniquely poised to offer services by leveraging its trusted brand, rich experience and broad reach.
Standards for Raw Food Certification
A recent trend has seen people shifting to Raw Food. However, there are no standards of what defines Raw Food. This paper by ICIS lays down standards for defining what is really Raw food.
CytoSolve: A Scalable Computational Method for Dynamic Integration of Multiple Molecular Pathway Models
This paper describes a new system called CytoSolve that dynamically integrates computations of smaller models that can run in parallel across different machines without the need to merge the source codes of the individual models.
Biomimetics of Communication and Media
The biomimetics of communication and media for the design of large-scale complex service systems is a relatively unexplored field. This paper provides a foundation for such research.
