ICIS Open Science SM Card-ver2

AML Initiative

Acute Myeloid Leukemia (AML) is a fast-progressing cancer of the blood and bone marrow, characterized by the abnormal proliferation of myeloid cells.

Phase I
Systems Architecture
Systems Architecture
Status: Completed
The Systems Architecture of AML is published as a web based tool open to public.
Phase II
Publications
Publications
Status: Completed
A peer-reviewed paper from the AML Initiative was published in 2022 in Cancers journal.
Phase III
In Silico Modeling
In Silico Modeling
Status: In Progress
In this phase, in silico modeling will develop mathematical models of AML pathogenesis. This phase is in progress.
Phase IV
Combination Screening
Combination Screening
Status: Open
Combination Screening will be conducted to identify compounds targeting biological processes in AML pathogenesis.
Phase V
Patents
Patents
Status: Open
In this phase, a US patent will be filed for the newly discovered combination(s).
Phase VI
Licensing and Manufacturing
Licensing and Manufacturing
Status: Open
The AML Initiative will license and manufacture nutraceuticals to support treatment of AML.

Background on AML

Acute Myeloid Leukemia (AML) is a fast-progressing cancer of the blood and bone marrow, characterized by the abnormal proliferation of myeloid cells. These cancerous cells hinder the production of healthy blood cells, leading to anemia, infections, and bleeding complications. AML primarily affects older adults, with a higher incidence in individuals over 60 years. It is the most common type of acute leukemia in adults, accounting for about 1% of all cancers globally. The disease progresses rapidly, requiring immediate medical attention. Despite advancements in chemotherapy, stem cell transplants, and targeted therapies, AML remains challenging to treat due to high relapse rates. Early diagnosis and personalized treatment approaches are crucial for improving patient outcomes.

Systems Architecture

The Systems Architecture of AML is published as a web based tool open to public. Click below to interact with the Systems Architecture.

Publication

A peer-reviewed publication resulting from the work of AML initiative was published in 2022 in the Cancers Journal. Download the paper below

In Silico Modeling

In this phase, the AML Initiative will conduct in silico modeling to identify and test the efficacy of natural ingredients on immunosuppression and cell proliferation activity. This phase is yet to begin.

Combination Screening

In this Phase, natural ingredients were identified and selected to be combined that had optimal effect on the biomarkers . The dose levels of ingredients will be finalized in the optimal combination this Phase, natural ingredients were identified and selected to be combined that had optimal effect on the biomarkers . The dose levels of ingredients will be finalized in the optimal combination

Patents

The Open Science Institute® through its AML initiative is moving towards getting patents for a revolutionary compounds that affects cell proliferation and immune suppression activity.

Licensing and Manufacturing

The AML Health Initiative plans to discover, develop, license and manufacture proprietary nutraceuticals to support treatment of AML Support our mission to bring this innovation to those who need it most. Please support this phase by donating to the AML Initiative.

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