Web-Enabled Molecular Systems Architecture of Asthma

V. A. Shiva Ayyadurai* and Prabhakar Deonikar*

*Systems Biology Group, CytoSolve Research Division, CytoSolve, Inc., Cambridge, MA 02138, USA

A multi-scale molecular systems architecture will be created to provide a comprehensive and integrative molecular systems understanding of Asthma. The architecture will be constructed through a supervised bioinformatics process, beginning with more scientific papers curated to a refined set of selected, targeted papers from which molecular interactions will be extracted. The systems architecture will be accessed through an easy-to-use interface to traverse the complexity of Asthma systems biology, from tissue to cell to an ensemble of molecular interactions, whereby one will be able to discover the particular paper from which an interaction is derived. The systems architecture will maintain its currency by enabling the research community to provide feedback that can be reviewed, refereed, and incorporated. The architecture will provide a framework for developing new educational tools, as well as to support research that aims to investigate disease mechanisms and identify potential therapeutic targets for the treatment of Asthma.

The purpose of this page will be to provide the Asthma research community with this open-sourced, web-enabled architecture, from which they can provide continual feedback so this architecture may be updated and curated based on such feedback to reflect the current understanding. Given this will be a work in progress, the top of this page will denote the current version number, and a link will be provided to release notes on any changes that were made to previous versions.